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S -dichlorovinyl, such as N -acetyl- S -(1,2-dichlorvinyl)-L-cysteine and S -(1,2-dichlorovinyl)-L-cysteine, induce toxicity towards the cells responsible for their production (Spencer and Schaumburg, 1985

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In aged animal models, growth hormone secretion is typically reduced by 50-70% compared to young adult levels, contributing to many of the physiological changes associated with aging including alterations in muscle mass, increased adiposity, reduced bone density, modified immune parameters, and decreased tissue repair capacity

This results in defects in mitophagy, whereas a large number of dysfunctional mitochondria are not removed in time and excessively accumulate in neuronal cells, which induces a vicious circle-chain reaction (Wong and Holzbaur, 2014)

doi: 10.1016/j.ejphar.2023.175549 136 NoorR.NazA.ManihaS